L-isoleucine in the field of biomedicine

The patent layout of L-isoleucine in the biomedical field mainly focuses on its applications in drug preparation, extraction processes, etc., with relevant analysis as follows:

In Drug Preparation

L-isoleucine can be used to prepare various drug formulations, and related patents involve the treatment of multiple diseases. For example, a patent discloses the use of L-serine and L-isoleucine in preparing pharmaceutical compositions for treating or preventing psoriasis. As an essential amino acid participating in multiple physiological processes, L-isoleucine leverages its biological functions in such patents to develop therapeutic drugs for specific diseases, expanding its application scope in biomedicine.

In Fermentation Production

Microbial fermentation is the primary method for L-isoleucine production, with many patents dedicated to improving yield and purity through strain modification:

A PCT application by CJ First Sugar discloses novel acetohydroxyacid synthase variants. When applied to Corynebacterium, these variants enhance L-isoleucine productivity.

Some patents overexpress L-isoleucine synthesis-related genes in E. coli, strengthen the synthetic pathway, block bypass routes, reduce by-product L-valine accumulation, and improve L-isoleucine conversion.

These patents aim to optimize fermentation processes, reduce costs, and enhance production efficiency to meet biomedical demands for L-isoleucine.

In Extraction Processes

To obtain high-purity L-isoleucine for biomedicine, patent layouts cover multiple extraction technologies:

"A full-membrane method for extracting L-isoleucine" combines membrane technology with flocculants for impurity removal, improving product yield and purity while recycling by-products to achieve energy conservation and emission reduction.

"A clean production process for extracting L-isoleucine from fermentation broth by ion exchange" realizes zero discharge of ammonium-containing wastewater through recycling waste liquid from ion exchange column regeneration, reducing wastewater treatment difficulty and enhancing economic benefits.

Conclusion

The patent layout of L-isoleucine in biomedicine covers multiple links from production to application. With technological advancements and deeper functional research, more related patents are expected in new drug development, production process optimization, etc., further improving its patent landscape.