DL-Alanine Supplier Quotation,Dosage Safety

DL-Alanine is a chemical compound with the molecular formula C3H7NO2. It is easily soluble in hot water, also soluble in water, but slightly soluble in ethanol. It can be used as a raw material for the production of Vitamin B6 and plays a role in medical microbiology and biochemistry amino acid metabolism.

The toxicity and safety assessment of dl-alanine is a comprehensive process that involves various data and experimental evidence.

Ⅰ.Toxicity Assessment

1. Acute Toxicity:

According to relevant experimental data, dl-alanine exhibits no toxic effects in acute oral toxicity tests. In an acute oral toxicity test on rats, the oral LD50 (lethal dose for 50% of the population) for both male and female rats was greater than 10,000 mg/kg body weight (BW), indicating that dl-alanine has low toxicity in acute exposure conditions for rats.

2. Chronic Toxicity:

In a 28-day oral toxicity test, the general condition of rats remained normal, and there were no significant changes in body weight gain, food intake, food utilization rate, or other indicators. No meaningful abnormal changes were observed in routine blood tests, coagulation, blood biochemistry, or urine tests. However, the kidney weight ratio in the high-dose male rat group showed a statistically significant difference compared to the control group, suggesting that dl-alanine might have some effect on the kidneys under high-dose, long-term exposure. However, pathological examination did not reveal any pathological changes related to the tested substance, indicating that the specific mechanism and significance of this effect need further investigation.

Ⅱ.Safety Assessment

1. Human Safety:

Alanine is a non-essential amino acid involved in protein synthesis in the body. Its safety and effectiveness primarily depend on whether it is normally metabolized and utilized by the body. Abnormal metabolism of alanine could lead to liver damage, causing symptoms such as fatigue and loss of appetite. Therefore, moderate intake of dl-alanine is safe for humans, but excessive or long-term high intake could have adverse health effects.

2. Environmental Safety:

DL-alanine may pose a hazard to the environment, especially to aquatic systems. Special attention should be paid to the treatment of packaging and chemicals contaminated by dl-alanine. Appropriate safety disposal methods should be adopted to prevent environmental pollution.

DL-alanine has low toxicity in acute exposure to rats, but may have some effect on the kidneys under long-term, high-dose exposure. For humans, moderate intake of dl-alanine is considered safe, but excessive or long-term intake may have negative health impacts. Therefore, when using dl-alanine, it is important to strictly control the intake amount and exposure duration and monitor its effects on both human health and the environment. Further research is also needed to explore the long-term toxicity and safety issues of dl-alanine.

The above information is for reference only. For more detailed and accurate data, it is recommended to consult relevant professional literature or seek advice from professionals.